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In mammals other than man and the great apes, the enzyme uricase breaks uric acid into the more soluble allantoin, which can be more easily excreted in the urine

Additionally, inhibition of the mammalian target of rapamycin (mTOR) with everolimus reduced the levels of tau and amyloid precursor protein/amyloid (APP/A) and improved cognitive function

In vivo studies using C57BL/6 mice, treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to induce PD, validated the therapeutic efficacy of the nanoparticles administered intravenously

Urinary volume are obtained in individual metabolic cage